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Cayman Chemical JasmonIc AcId methyl ester 1g
Supplier: Cayman Chemical 90000591 G
A non-steroidal mineralocorticoid receptor antagonist (IC50 9.4 nM) selective for mineralocorticoid receptors over glucocorticoid androgen and progesterone receptors (IC50s >10000 nM for all) increases the urinary ratio of sodium to potassium in bilateral adrenalectomized rats at 0.3 1 or 3 mg/kg decreases systolic blood pressure in DOCA-salt hypertensive rats at 3 mg/kg reduces systolic blood pressure urinary protein levels blood levels of BNP kidney and left ventricle weights and glomerulosclerosis as well as increases blood potassium levels in Dahl salt-sensitive rats fed a high-salt diet at 2 mg/kg per day
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