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Medchemexpress LLC Jatrorrhizine (chloride) | 6681-15-8 | 373.83 | 1 ML
Supplier: Medchemexpress LLC HYN074010MM/1ML
Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis that possesses neuroprotective, antimicrobial, antiplasmodial, and antioxidant activities. It acts as a potent and orally active inhibitor of AChE (IC50=872 nM), demonstrating over 115-fold selectivity for BuChE. Additionally, it reduces the uptake of serotonin (5-HT) and norepinephrine (NE) by inhibiting uptake-2 transporters.
- Neuroprotective activity
- Antimicrobial activity
- Antiplasmodial activity
- Antioxidant activity
- Potent and orally active inhibitor of AChE
- Over 115-fold selectivity for BuChE
- Reduces uptake of serotonin (5-HT) and norepinephrine (NE)
- Inhibits PMAT-mediated MPP+ uptake
- Inhibits 5-HT and NE uptake in synaptosomes
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