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Medchemexpress LLC JBI-589 | 2308504-22-3 | C29H28FN5O | 1 MG
Supplier: Medchemexpress LLC HY1534501MG
JBI-589 is a non-covalent, orally bioavailable, and isoform-selective inhibitor of PAD4. It reduces CXCR2 expression and blocks neutrophil chemotaxis, and has been shown to reduce primary tumor and metastases. This compound enhances the anti-tumor effect of checkpoint inhibitors, making it suitable for cancer research.
- Non-covalent and orally bioavailable
- Isoform-selective inhibitor of PAD4
- Reduces CXCR2 expression and blocks neutrophil chemotaxis
- Inhibits primary tumor growth and metastases
- Enhances anti-tumor effect of checkpoint inhibitors
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