Medchemexpress LLC JCN037 (JGK037) | 2305154-31-6 | 99.1% | 376.18 | 1 ML

Supplier:  Medchemexpress LLC HY13643010MM/1ML

JCN037 (JGK037) is a non-covalent and BBB-penetrant EGFR tyrosine kinase inhibitor, with IC50 values of 2.49 nM, 3.95 nM, and 4.48 nM for EGFR, p-wtEGFR, and pEGFRvⅢ, respectively. It exhibits GI50 values of 329 nM in HK301 cells and 1116 nM in GBM39 cells. In vivo, it downregulates pEGFRvⅢ, p Akt, p-ERK, and p-S6 protein levels and provides a significant survival benefit, increasing median survival by 47% from 37.5 days to 55 days.

• Non-covalent EGFR tyrosine kinase inhibitor.
• BBB-penetrant.
• Inhibits EGFR (IC50: 2.49 nM).
• Effective in HK301 (GI50: 329 nM) and GBM39 (GI50: 1116 nM) cells.
• Downregulates key protein phosphorylation.
• Increases median survival by 47% in vivo.

Catalog No. 50-003-49663