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Medchemexpress LLC JGB1741 | 1256375-38-8 | 99.4% | 440.56 | 10 MG
Supplier: Medchemexpress LLC HY111329100MG
JGB1741 is a potent and specific SIRT1 activity inhibitor with an IC50 of approximately 15 μM, demonstrating weaker inhibition against SIRT2 and SIRT3 with IC50 values greater than 100 μM. This compound increases acetylated p53 levels, leading to p53-mediated apoptosis through the modulation of Bax/Bcl2 ratio, cytochrome c release, and PARP cleavage. It shows potential for breast cancer research, inhibiting MDA-MB 231 cell proliferation more potently than K562 and HepG2 cells. JGB1741 induces apoptosis and cell cycle arrest at the G1 phase in MDA-MB 231 cells, causing a dose-dependent increase in global acetylation of H3K9, p53 expression, and acetylated p53K382 levels in these cells.
- Potent and specific SIRT1 activity inhibitor.
- Increases acetylated p53 levels.
- Induces apoptosis and cell cycle arrest.
- Causes a dose-dependent increase in global acetylation.
- Potential for breast cancer research.
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