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Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 1 ML
Supplier: Medchemexpress LLC HY11214010MM/1ML
JH-VIII-157-02 is a structural analogue of alectinib, functioning as an ALK inhibitor. It demonstrates potent inhibition of various EML4-ALK mutants and exhibits selectivity against other kinases. This compound shows inhibitory growth in several cancer cell lines and possesses good oral bioavailability, with the ability to penetrate the CNS in mice.
- Potently inhibits EML4-ALK G1202R, EML4-ALKwt, and other EML4-ALK mutants
- Demonstrates selectivity against IRAK1, CLK4, RET, and IRAK4
- Exhibits inhibitory growth in H3122 and DFCI76 cancer cell lines
- Good oral bioavailability in mice
- Penetrates the central nervous system in mice
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