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Apexbio Technology LLC JNJ-10198409 627518-40-5 5mg
Supplier: Apexbio Technology LLC C57375
JNJ-10198409 (CAS 627518-40-5) is a small molecule inhibitor targeting the tyrosine kinase activity of the platelet-derived growth factor (PDGF-BB) receptor This compound acts as a competitive antagonist at the ATP-binding site of the PDGF-BB receptor thereby inhibiting downstream signaling involved in cell proliferation migration and angiogenesis In human coronary artery smooth muscle cells JNJ-10198409 demonstrated an IC50 of 4 2 nM for inhibition of PDGF-BB receptor kinase activity It has been utilized in research to study the modulation of tumor growth angiogenesis and PDGF-driven pathologies
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