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Cayman Chemical JNJ-10229570 10mg
Supplier: Cayman Chemical 3776810 MG
A melanocortin receptor antagonist (IC50s = 270, 240, and 200 nM for MC1R, MC4R, and MC5R, respectively, in radioligand binding assays); prevents bovine pituitary extract-induced increases in lipid droplets in primary human sebocytes at 0.05 µM; inhibits cholera toxin-induced increases in squalene and cholesterol esters, but not triglycerides, in primary human sebocytes at 1 µM; topical application inhibits sebum secretion from, and sebaceous gland differentiation in, transplanted human skin in a mouse xenograft model at 0.05%
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