Medchemexpress LLC JNJ-10397049 | 708275-58-5 | 99.2% | 484.18 | 5 MG

Supplier:  Medchemexpress LLC 5MGHY10896

JNJ-10397049 is a potent and selective orexin 2 receptor (OX2R) antagonist, with a pKi of 8.3. It is 600-fold selective for the OX2R over the OX1R. For research use only. In vivo, JNJ-10397049 (10-30 mg/kg) decreases the latency for persistent sleep and increased nonrapid eye movement and rapid eye movement sleep time. It also blocks ethanol self-administration, place preference, and reinstatement.

• Decreases the latency for persistent sleep and increases nonrapid eye movement and rapid eye movement sleep time.
• Blocks ethanol self-administration, place preference, and reinstatement.
• In vitro solubility: DMSO: 170 mg/mL (351.11 mM).
• In vivo suspended solution protocol: 10% DMSO, 40% PEG300, 5% Tween-80, 45% Saline; solubility: 4.25 mg/mL (8.78 mM).
• In vivo clear solution protocol: 10% DMSO, 90% Corn Oil; solubility: ≥ 4.25 mg/mL (8.78 mM).

Catalog No. 50-003-65963