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Medchemexpress LLC JNJ-28583113 | 2765255-93-2 | 98.8% | 366.38 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY149143

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JNJ-28583113 is a brain-permeable TRPM2 antagonist. It inhibits TRPM2-blocked phosphorylation of GSK3α and β subunits, protecting cells from oxidative stress-induced cell death and suppressing cytokine release in response to pro-inflammatory stimuli in microglia.

  • Inhibits TRPM2 in cells overexpressing chimpanzee, rat, and human TRPM2.
  • Prevents cells from H2O2 induced cell death.
  • Protects HeLa cells from H2O2 induced morphological changes.
  • Achieves 400 ng/mL in the brain compartment.
  • Quickly metabolized in plasma.

Catalog No. 50-003-63208


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