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Medchemexpress LLC JNJ-28583113 | 2765255-93-2 | >98.8% | 366.38 | 250 MG
Supplier: Medchemexpress LLC 250MGHY149143
JNJ-28583113 is a brain-permeable TRPM2 antagonist. It inhibits TRPM2-blocked phosphorylation of GSK3α and β subunits, protects cells from oxidative stress-induced cell death, and suppresses cytokine release in response to pro-inflammatory stimuli in microglia.
- Inhibits TRPM2 in cells (IC50=100 nM chimpanzee, 25 nM rat, 126 nM human)
- Prevents cells from H2O2 induced cell death up to 1 mM of H2O2
- Protects HeLa cells from H2O2 induced morphological changes
- Brain penetrant and achieves 400 ng/mL in the brain compartment
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