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Cayman Chemical JNJ-37822681hydrochlorIde 25mg
Supplier: Cayman Chemical 3742825 MG
A dopamine D2L receptor antagonist (Ki = 0.158 µM); selective for dopamine D2L receptors over dopamine D1 and D3, α1-adrenergic, and histamine H1 receptors, and the 5-HT receptor subtypes 5-HT2A and 5-HT2C in radioligand binding assays (Kis = >3, 1.159, >5, 4.931, 2.896, and >4 µM, respectively); inhibits apomorphine-induced stereotypy and D-amphetamine-induced hyperlocomotion in rat models of psychosis (ED50s = 0.19 and 1 mg/kg, respectively)
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