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Medchemexpress LLC JNJ-46778212 | 1363281-27-9 | 99.6% | 352.36 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY1955910MM/1ML

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JNJ-46778212 (VU 0409551) is an mGlu5 positive allosteric modulator with an EC50 of 260 nM. This compound demonstrates excellent CNS penetration in oral brain/plasma studies and enhances NMDAR function. It restores long-term potentiation in hippocampal slices and reverses deficits in neuroplasticity signaling pathways, leading to improved contextual fear memory.

  • Mglu5 positive allosteric modulator
  • Excellent CNS penetration
  • Enhances NMDAR function
  • Restores long-term potentiation
  • Reverses deficits in neuroplasticity signaling pathways
  • Improves contextual fear memory

Catalog No. 50-004-01971


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