Apexbio Technology LLC JNK-IN-7 1408064-71-0 5mg

Supplier:  Apexbio Technology LLC A35195

JNK-IN-7 (CAS 1408064-71-0) is a selective inhibitor targeting c-Jun N-terminal kinases (JNK) exhibiting potent inhibitory activity against JNK1 JNK2 and JNK3 with IC50 values of 1 54 nM 1 99 nM and 0 75 nM respectively Mechanistically JNK-IN-7 blocks phosphorylation of c-Jun a direct downstream substrate of JNK signaling Additionally this compound requires Cys116 in JNK2 for effective inhibition Cellular studies demonstrate that JNK-IN-7 at micromolar concentrations inhibits IRAK1-dependent activation of Pellino an E3 ubiquitin ligase implicated in Toll-like receptor signaling and suppresses c-Jun phosphorylation in RAW264 7 macrophages stimulated by Pam3CSK4 JNK-IN-7 serves as a research tool in studying JNK signaling pathways and innate immune responses

Catalog No. 50-000-63172