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Medchemexpress LLC JX06 | 729-46-4 | 99.78% | 324.51 | 1 ML
Supplier: Medchemexpress LLC HY1956410MM/1ML
JX06 is a potent, selective, and covalent inhibitor of Pyruvate Dehydrogenase Kinase (PDK), inhibiting PDK1, PDK2, and PDK3 with varying IC50s. It functions by irreversibly binding to a cysteine residue in PDK1 and has demonstrated significant antitumor activity in both in vitro and in vivo studies.
- Potent, selective, and covalent PDK inhibitor.
- Inhibits PDK1, PDK2, and PDK3.
- Induces cell apoptosis in various cancer cell lines.
- Suppresses cancer cell growth.
- Inhibits PDHA1 phosphorylation.
- Increases glucose uptake and intracellular ATP.
- Reduces aerobic glycolysis.
- Induces ROS generation in cancer cells.
- Demonstrates in vivo tumor growth inhibition.
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