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Apexbio Technology LLC JZL184 1101854-58-3 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B19585.1
JZL184 (CAS 1101854-58-3) is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) a serine hydrolase that hydrolyzes the endocannabinoid 2-arachidonoylglycerol (2-AG) In murine models JZL184 inhibits MAGL-mediated 2-AG hydrolysis with an IC50 of 8 nM resulting in elevated brain 2-AG concentrations Electrophysiological studies demonstrate that JZL184 modulates synaptic plasticity in cerebellar and hippocampal neurons via CB1 receptor-dependent mechanisms such as delayed depolarization-induced suppression of inhibition and excitation In vivo JZL184 elicits CB1-dependent behaviors including analgesia and hypothermia and exhibits anxiolytic and antinociceptive effects in rodent models This compound is widely used to investigate endocannabinoid signaling and MAGL function in neurobiological research
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