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Enzo Life Sciences K-252a (100µg). CAS: 99533-80-9
SDP

Supplier:  Enzo Life Sciences BMLEI1520100

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Alkaloid isolated from soil fungi. General, cell permeable protein kinase inhibitor. Acts by binding to the ATP binding domain of the kinase. Potent inhibitor of Ca2+/calmodulin kinase II. Inhibits myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) (Ki=25nM), trk tyrosine kinase family members (gp140trk; IC50 =3nM) and cGMP-dependent protein kinase (PKG). Binds with high affinity to neuroblastoma membrane (2.7nM), promoting survival of primary neuronal cultures (75nM) and induction of neurite outgrowth in SH-SY5Y neuroblastoma cells along with phosphorylation of pp125 focal adhesion protein tyrosine kinase. Induces apoptosis. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (1mg/ml) or dimethyl formamide (1mg/ml). Long Term Storage: -20°C.

Catalog No. 50-201-0571


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