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AdipoGen K777 [K11777] (5 mg)
SDP

Supplier:  AdipoGen AGCR10158M005

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K777 [K11777] (5 mg), AdipoGen Life Sciences. Chemical. CAS: 233277-99-1. Formula: C32H38N4O4S. MW: 574.7. Synthetic. Broad-range cathepsin inhibitor (for all known cathepsins) useful for inflammasome inhibition. Inhibits cathepsins B, L, S, C, V, K and papain in cell-free assays. Inhibits cathepsin X as well. Suppresses particle-induced NLRP3 activation and IL-1beta secretion more efficiently than Ca074Me (cathepsin B inhibitor), which in contrast suppresses nigericin-induced IL-1beta secretion. Selectively inhibits particle-induced cell death but not nigericin- or sAdT-induced cell death. Potent and selective CCR4 antagonist. Potent, irreversible cysteine protease inhibitor. Potent cysteine protease cruzain (cruzipain) inhibitor.

Catalog No. 50-149-0071


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