Medchemexpress LLC Kan0438757 | 1451255-59-6 | 99.4% | 447.43 | 50 MG

Supplier:  Medchemexpress LLC HY11280850MG

KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM. Intended for research use only, this product demonstrates inhibition of cell viability across various cell lines. It also reduces PFKFB3 protein expression and glycolysis, while decreasing homologous recombination activity and increasing ionizing radiation induced γH2AX foci level. In vivo studies confirm its good tolerability and absence of systemic toxic effects.

• Potent and selective PFKFB3 inhibitor
• Inhibits cell viability in multiple cell lines
• Decreases homologous recombination activity
• Increases ionizing radiation induced γH2AX foci level
• Reduces PFKFB3 protein expression
• Reduces glycolysis in cancer cells and HUVECs
• Well tolerated with no systemic toxic effects in vivo

Catalog No. 50-004-36187