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Medchemexpress LLC KB-5492 free base | 113594-64-2 | 99.02% | C23H30N2O6 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY47228100MG

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The compound is a potent and selective inhibitor of the sigma receptor. It inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. It also functions as an anti-ulcer agent.

  • Sigma receptor inhibition: It is a potent and selective inhibitor of the sigma receptor, showing an IC50 of 3.15 μM for sigma receptor binding.
  • Anti-ulcer agent: The compound has been identified as an anti-ulcer agent.
  • In vitro activity: It inhibits specific [3H]DTG binding in a concentration-dependent manner. It also significantly and concentration-dependently prevents ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells.
  • In vivo activity: When administered orally at 200 mg/kg, it prevents macroscopic lesions in the gastric mucosa, reducing lesion length and preventing deep mucosal lesions and exfoliation of surface epithelial cells in animal models.

Catalog No. 50-003-58469


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