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AdipoGen Ketoconazole
Supplier: AdipoGen CDXK0016G005
Chemical. CAS 65277-42-1. Formula C26H28Cl2N4O4. MW 531.43. Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans and A. fumigatus strains IC50s = 0.031-8 µg/ml. It inhibits the fungal cytochrome P450 CYP isoform CYP51, also known as lanosterol 14alpha-demethylase, which arrests ergosterol biosynthesis at the fungal membrane. This interaction inhibits ergosterol synthesis and results in increased fungal cellular permeability. Ketoconazole also inhibits human CYP3A4 IC50 = 0.54 µM. Formulations containing ketoconazole have been used in the treatment of fungal infections. Ketoconazole blocks in humans activity of several enzymes necessary for the conversion of cholesterol to steroid hormones such as testosterone and cortisol.
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