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Medchemexpress LLC Ki-tox-a3 | 1351116-34-1 | >99.15% | 319.31 | 25 MG
Supplier: Medchemexpress LLC 25MGHY176244
KI-TOX-A3 is a selective protein-protein interaction (PPI) inhibitor targeting the TOX protein, with an IC50 value of 0.51 μM for TOX-KAT7 interaction. It induces proteasomal degradation of TOX, which restores KAT7-mediated H3K14 acetylation. This action reverses CD8+ T cell exhaustion and inhibits the proliferation of T-cell acute lymphoblastic leukemia (T-ALL) cells. KI-TOX-A3 shows promise for research in hematological tumors such as T-ALL.
- Selective PPI inhibitor targeting TOX protein
- Induces proteasomal degradation of TOX
- Restores KAT7-mediated H3K14 acetylation
- Reverses CD8+ T cell exhaustion
- Inhibits T-cell acute lymphoblastic leukemia (T-ALL) cell proliferation
- Promising for research of hematological tumors
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