Medchemexpress LLC KI-TOX-A3 | 1351116-34-1 | 99.15% | 319.31 | 5 MG

Supplier:  Medchemexpress LLC HY1762445MG

KI-TOX-A3 is a selective protein-protein interaction (PPI) inhibitor that targets the TOX protein. It has an IC50 value of 0.51 μM for the TOX-KAT7 interaction. This compound induces proteasomal degradation of TOX, which restores KAT7-mediated H3K14 acetylation, thereby reversing CD8+ T cell exhaustion and inhibiting the proliferation of T-cell acute lymphoblastic leukemia (T-ALL) cells. KI-TOX-A3 shows promise for research into hematological tumors like T-ALL. It is intended for research use only and not for sale to patients.

• Selective protein-protein interaction (PPI) inhibitor targeting TOX protein.
• Induces proteasomal degradation of TOX.
• Restores KAT7-mediated H3K14 acetylation.
• Reverses CD8+ T cell exhaustion.
• Inhibits T-cell acute lymphoblastic leukemia (T-ALL) cell proliferation.
• Promising for research of hematological tumors (e.g., T-ALL).

Catalog No. 50-003-87290