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Apexbio Technology LLC Kifunensine(Synonyms: Kif, Kifu, Kifunensin, KY-12420, Mannosidase inhibitor Kifunensine), 50mg, CAS: 109944-15-2.
Supplier: Apexbio Technology LLC B731550
Kifunensine (CAS 109944-15-2) is a selective inhibitor of class I -mannosidases enzymes critical for glycoprotein processing and folding It primarily inhibits human endoplasmic reticulum -1 2-mannosidase I and Golgi -mannosidases IA IB and IC with Ki values of approximately 130 nM and 23 nM respectively Additionally it suppresses plant-derived -1 2-mannosidase I at IC50 values between 20 50 nM By blocking -mannosidase I activity in the endoplasmic reticulum (ER) kifunensine prevents the ER-associated degradation of misfolded glycoproteins thus serving as an investigative tool in studies of protein quality control pathways and glycoprotein biosynthesis
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