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Enzo Life Sciences Ko143 (5mg). CAS: 461054-93-3
Supplier: Enzo Life Sciences BMLEI3960005
Analog of the fungal toxin fumitremorgin C (ALX-350-127). Potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP, EC90=26nM). Highly effective for increasing the intracellular drug accumulation and reversing BCRP-mediated multidrug resistance yet has little activity against P-glycoprotein, multidrug resistance-associated protein (MRP1) and other known drug transporters. In mouse models Ko143 was able to restore the intracellular accumulation and abolish the directionality in net flux of dasatinib. It is a highly useful tool for the identification of drug transport processes in complex experimental systems. Alternative name: (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino-[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester. Purity: ≥96% (HPLC). Solubility: Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). Long Term Storage: -20°C.
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