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Medchemexpress LLC Benzoic acid, 4-[4-[(2-bromoacetyl)amino]butyl]- | 10161-87-2 | 98.7% | 314.18 | 10 MM * 1 ML
SDP

Supplier:  Medchemexpress LLC HY13818810MM/1ML

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KRA-533 is a potent KRAS agonist that functions by binding to the GTP/GDP binding pocket in the KRAS protein, which prevents GTP cleavage. This action leads to the accumulation of constitutively active GTP-bound KRAS, subsequently triggering both apoptotic and autophagic cell death pathways in cancer cells.

  • Potent KRAS agonist
  • Binds to GTP/GDP binding pocket in KRAS protein
  • Prevents GTP cleavage
  • Triggers apoptotic and autophagic cell death pathways in cancer cells
  • Enhances KRAS activity
  • Suppresses tumor growth in lung cancer mutant KRAS xenografts
  • Induces apoptosis and autophagy in tumor tissues
  • Directly binds to WT, G12C, G12D, and G13D mutant KRAS proteins

Catalog No. 50-003-50758


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