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Medchemexpress LLC Benzoic acid, 4-[4-[(2-bromoacetyl)amino]butyl]- | 10161-87-2 | 98.7% | 314.18 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY138188

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KRA-533 is a potent KRAS agonist that binds to the GTP/GDP binding pocket in the KRAS protein to prevent GTP cleavage. This results in the accumulation of constitutively active GTP-bound KRAS, triggering apoptotic and autophagic cell death pathways in cancer cells.

  • Enhances KRAS activity in HCC827 and H157 cells.
  • Mediates cell growth suppression in H292 cells without KRAS mutation.
  • Directly binds to WT, G12C, G12D, and G13D mutant KRAS proteins.
  • Suppresses tumor growth and induces apoptosis and autophagy in mutant KRAS xenografts in vivo.

Catalog No. 50-003-48108


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