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Medchemexpress LLC KRN5 | 1800465-47-7 | 98.8% | 459.47 | 100 MG
Supplier: Medchemexpress LLC HY112126100MG
KRN5, a derivative of KRN2, is an orally active suppressor of Nuclear Factor of Activated T cells 5 (NFAT5), with an IC50 of 750 nM. It has potential for treating NFAT5-mediated Chronic Arthritis.
- Less toxic than BBR as determined by cytotoxicity, hERG K+ channel, cytochrome inhibition, and liver microsomal metabolic stability tests.
- Inhibits expression of NFAT5, IL-6, MCP-1, and GM-CSF in RAW264.7 macrophages stimulated with LPS at 1 μM.
- Oral administration mitigates arthritis severity in a dose-dependent manner.
- Significantly decreases serum anti-type II collagen IgG in treated mice.
- Lowers TNF-α and IL-6 production by LPS-stimulated splenocytes in treated CIA mice.
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