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Medchemexpress LLC KT109 | 1402612-55-8 | 99.9% | 422.52 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY18540

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KT109 is a potent and isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC50 of 42 nM. It demonstrates significant selectivity for DAGLβ over DAGLα and influences a lipid network crucial for macrophage inflammatory responses. This compound effectively lowers levels of 2-Arachidonoylglycerol, Arachidonic acid, and eicosanoids.

  • Inhibits diacylglycerol lipase-β (DAGLβ) activity.
  • Shows selectivity for DAGLβ over DAGLα.
  • Reduces cellular 2-arachidonoylglycerol and arachidonic acid.
  • Modulates lipid networks involved in macrophage inflammatory responses.
  • Reverses allodynic responses in models of inflammatory and neuropathic pain.

Catalog No. 50-003-84899


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