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Medchemexpress LLC KTX-582 | 2573298-13-0 | 98.7% | 872.93 | 1 MG
Supplier: Medchemexpress LLC HY1482741MG
KTX-582 is a potent IRAK4 degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively. It can induce apoptosis in MYD88MT DLBCL and is efficient at inducing in vivo tumor regressions in a lymphoma model.
- Potent IRAK4 degrader
- Induces apoptosis in MYD88MT DLBCL
- Efficient at inducing in vivo tumor regressions in lymphoma models
- Degrades IRAK4 in whole blood monocyte and lymphocyte with IC50s of <0.05 μM
- Inhibits IRAK4 in human whole blood LPS TNFα with an IC50 of 0.05-1 μM
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