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Apexbio Technology LLC KU-0063794 938440-64-3 25mg
Supplier: Apexbio Technology LLC A507825
KU-0063794 (CAS 938440-64-3) is a highly selective ATP-competitive inhibitor of mTOR kinase effectively targeting both mTORC1 and mTORC2 complexes with an IC50 of approximately 10 nM In cellular assays KU-0063794 inhibits mTORC1-mediated phosphorylation of S6K1 and S6 protein as well as mTORC2-dependent Akt and SGK phosphorylation The compound displays minimal inhibitory activity against other kinases including class I PI3Ks KU-0063794 has been used to delineate mTOR pathway functions in various models and demonstrates the ability to suppress leukemic cell proliferation and colony formation in BCR/ABL-driven settings highlighting its utility in mTOR signaling and cancer research
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