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Medchemexpress LLC KWCN-41 | 2913223-17-1 | 99.8% | 307.35 | 100 MG
Supplier: Medchemexpress LLC HY149258100MG
KWCN-41 is a selective and efficient inhibitor of RIPK1 kinase with an IC50 value of 88 nM. It specifically inhibits cell necrosis but does not inhibit apoptosis and also exhibits anti-inflammatory effects.
- Inhibits L929 cell necroptosis
- Increases viable cell numbers
- Inhibits phosphorylation of RIPK1/3 and MLKL
- Protects HT-29 and U937 cells from necroptosis
- Improves survival in inflammatory mouse model
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