Apexbio Technology LLC KX2-391 897016-82-9 250mg

Supplier:  Apexbio Technology LLC B2282250

KX2-391 (CAS 897016-82-9) is a highly selective non-ATP competitive inhibitor of Src kinase targeting the substrate-binding site rather than the ATP-binding domain With an IC50 of 20 nM against Src KX2-391 suppresses Src-catalyzed phosphorylation of FAK Shc and paxillin as well as Src autophosphorylation without impacting kinases such as PDGFR EGFR JAK1 JAK2 or Lck Additionally KX2-391 inhibits tubulin polymerization by binding to specific sites on the tubulin heterodimer Cellular assays demonstrate growth inhibition in NIH3T3/c-Src527F and SYF/c-Src527F cell lines with GI50 values of 23 nM and 39 nM respectively KX2-391 is utilized in research involving Src-related oncogenic signaling and tumor metastasis

Catalog No. 50-000-90460