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Cayman Chemical L-694 247trIfluoroACTAte25mg
Supplier: Cayman Chemical 4063925 MG
A 5-HT1D receptor agonist; selective for 5-HT1D over the 5-HT1A, 5-HT1C, 5-HT1E, 5-HT2, and 5-HT3 receptors (Kis = 0.093, 2.29, 380, 2,187, 316, and >10,000 nM, respectively); inhibits forskolin-induced adenylyl cyclase activity in guinea pig substantia nigra homogenates and potassium-induced 5-HT release in isolated guinea pig frontal cortex strips (EC50s = 0.79 and 0.4 nM, respectively); decreases water intake in dehydrated rats as well as prevents carbachol-, angiotensin II-, or isoproterenol-induced increases in water intake in normohydrated rats; intra-atrial administration (0.00000125-0.1 UG/kg) decreases renal perfusion pressure in in situ autoperfused rat kidney infused with phenylephrine
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