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Apexbio Technology LLC L189 64232-83-3 5mg
Supplier: Apexbio Technology LLC B74265
L189 (CAS 64232-83-3) is a small molecule inhibitor targeting human DNA ligases involved in DNA replication and repair Specifically L189 preferentially inhibits the adenylate transfer step of the ligation reaction without affecting T4 DNA ligase at concentrations up to 100 M In enzymatic assays L189 suppresses human DNA ligase I III and IV activity with IC50 values of 5 2 M 9 2 M and 5 2 M respectively Cellular studies show that L189 decreases viability and/or proliferation in epithelial and cancer cell lines such as HeLa MCF7 and HCT116 and enhances cell death particularly in colorectal cancer cells while sparing non-tumorigenic cells L189 serves as a valuable chemical probe for dissecting DNA ligase function in DNA repair and cancer biology research
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