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Apexbio Technology LLC Lactacystin (Synthetic) 133343-34-7 500ug
Supplier: Apexbio Technology LLC A25830.5
Lactacystin (Synthetic) is an irreversible proteasome inhibitor that selectively targets the catalytic subunits of the 20S proteasome inhibiting chymotrypsin-like trypsin-like and caspase-like enzymatic activities It exhibits an IC50 of approximately 4 8 M Lactacystin has been widely utilized as a research tool to study proteasome-mediated biological pathways Experimentally Lactacystin administration triggered neurite extension and transient cAMP elevation in Neuro-2a cells and induced cell-cycle arrest in MG-63 osteosarcoma cells In animal glioma xenograft models Lactacystin treatment at doses ranging from 1 to 5 g per 20 g body weight reduced tumor volume demonstrating its potential application in glioma research
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