Genscript Corporation LAG-3 CD223 Fc Chimera Huma

Supplier:  Genscript Corporation Z034221

Lymphocyte activation gene-3 (LAG-3) also known as CD223 is a cell-surface 70kDa molecule belong to Ig superfamily with diverse biologic effects on T cell function LAG-3 is a CD4 homolog originally cloned in 1990 The gene for LAG-3 lies adjacent to the gene for CD4 on human chromosome 12 (12p13) and is approximately 20% identical to the CD4 gene human LAG-3 shares 70% 67% 76% and 73% aa sequence identity with mouse rat porcine and bovine LAG-3 respectively LAG-3 is expressed on B cells NK cells tumor-infiltrating lymphocytes and a subset of T cells LAG-3 was relatively overexpressed on transgenic T cells rendered anergic in vivo by encounter with cognate self-antigen LAG-3 negatively regulates murine T cell activation and homeostasis LAG-3 activates antigen-presenting cells through MHC class II signaling leading to increased antigen-specific T-cell responses in vivo Blocking or knocking out LAG-3 in neuronal cultures or in animals mitigated the transmission of -sy

Catalog No. 50-000-59523