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Cayman Chemical Lanraplenb 5mg
Supplier: Cayman Chemical 325185 MG
A Syk inhibitor (IC50 = 6.2 nM); selective for Syk over a panel of 395 kinases but does inhibit JAK2 (IC50 = 120 nM); reduces anti-IgM- and anti-CD40-induced proliferation of isolated human B cells (EC50 = 108 nM); inhibits immune complex-induced production of TNF-α, IL-1β, and IL-6 in human macrophages (EC50s = 180, 90, and 700 nM, respectively); reduces proteinuria and increases survival in the NZBWF1 mouse model of SLE
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