Medchemexpress LLC Lapatinib | 231277-92-2 | 99.8% | C29H26ClFN4O4S | 100 MG

Supplier:  Medchemexpress LLC HY50898100MG

Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains. It has IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. Lapatinib treatment inhibits receptor autophosphorylation of EGFR and ErbB-2 in a dose-responsive manner, and the phosphorylation of serine 473 of AKT was also inhibited in a dose-dependent manner. It also shows selective inhibition of the proliferation of human tumor cell lines and induces G1 arrest. In vivo, Lapatinib inhibits tumor xenograft growth in a dose-responsive manner.

• Potent, orally active inhibitor of ErbB-2 and EGFR tyrosine kinase domains.
• Inhibits receptor autophosphorylation of EGFR and ErbB-2.
• Inhibits phosphorylation of serine 473 of AKT.
• Shows selective inhibition of human tumor cell line proliferation.
• Induces G1 arrest.
• Inhibits tumor xenograft growth in vivo.

Catalog No. 50-003-58158