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Apexbio Technology LLC Lapatinib(Synonyms: Tykerb, GW572016, Lapatinib ditosylate, GW-572016, Tyverb), 50mg, CAS: 231277-92-2.
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Supplier:  Apexbio Technology LLC A821850

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Lapatinib (CAS 231277-92-2) also known as GW572016 is a reversible small-molecule inhibitor targeting epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2) By competitively binding to the ATP-binding domain of these receptor tyrosine kinases Lapatinib reduces receptor autophosphorylation subsequently blocking downstream signaling pathways involved in cell survival and proliferation In biochemical kinase assays it exhibits inhibitory activity against recombinant EGFR and HER-2 with IC50 values of 10 8 nmol/L and 9 3 nmol/L respectively Lapatinib is employed in biomedical oncology research investigating targeted inhibition strategies in EGFR- and HER-2-associated cancers

Catalog No. 50-000-60472


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