Apexbio Technology LLC Lapatinib Ditosylate 388082-77-7 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A39675.1

Lapatinib Ditosylate (CAS 388082-77-7) is a reversible dual inhibitor of the ErbB-2 (HER2) and epidermal growth factor receptor (EGFR) tyrosine kinases It competitively binds to the ATP-binding sites of these receptors preventing activation and downstream signaling In vitro Lapatinib Ditosylate exhibits potent inhibition with IC50 values of 9 2 nM for ErbB-2 and 10 8 nM for EGFR and demonstrates over 300-fold selectivity compared to kinases such as MEK and ERK The compound suppresses proliferation and downstream phosphorylation events (Erk1/2 AKT) in cancer cell lines overexpressing ErbB-2/EGFR and induces G1 cell cycle arrest In vivo it reduces tumor growth in xenograft mouse models Lapatinib Ditosylate is widely utilized in studies exploring receptor tyrosine kinase function and targeted cancer therapies

Catalog No. 50-000-96588