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Medchemexpress LLC Lapatinib ditosylate monohydrate | 388082-78-8 | 100.0% | 50 MG
Supplier: Medchemexpress LLC HY50898B50MG
Lapatinib ditosylate monohydrate is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains. It has demonstrated IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. This compound is for research use only.
- Potent, orally active inhibitor of ErbB-2 and EGFR tyrosine kinase domains.
- Inhibits receptor autophosphorylation of EGFR and ErbB-2.
- Selectively inhibits proliferation of human tumor cell lines overexpressing EGFR or ErbB-2.
- Induces G1 arrest in HN5 cells.
- Inhibits tumor xenograft growth in vivo.
- Associated with numerous clinical trials for various cancers.
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