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Medchemexpress LLC Laroprovstat (AZD0780) | 2455427-91-3 | 99.9% | 414.41 | 50 MG
Supplier: Medchemexpress LLC HY14867350MG
Laroprovstat (AZD0780) is an orally active PCSK9 inhibitor. It has a binding affinity for PCSK9 with a Kd value of <200 nM. Laroprovstat binds to a pocket in the PCSK9 C-terminal domain without affecting the PCSK9-LDL receptor (LDLR) interaction. It inhibits the lysosomal trafficking of PSCK9-LDLR complexes and prevents PCSK9-induced LDLR degradation. It is used for the research of hypercholesterolemia.
- Orally active PCSK9 inhibitor
- High binding affinity for PCSK9 (Kd <200 nM)
- Inhibits lysosomal trafficking of PSCK9-LDLR complexes
- Prevents PCSK9-induced LDLR degradation
- Potential for hypercholesterolemia research
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