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Apexbio Technology LLC Larotrectinib 1223403-58-4 5mg
Supplier: Apexbio Technology LLC A46845
Larotrectinib (CAS 1223403-58-4) is a selective orally bioavailable inhibitor of tropomyosin receptor kinases (Trk) which are receptor tyrosine kinases implicated in oncogenic signaling upon neurotrophin activation By binding to Trk proteins larotrectinib disrupts neurotrophin-mediated phosphorylation and downstream signaling leading to growth inhibition and induction of apoptosis in tumor models with Trk gene fusions or overexpression It has gained regulatory approval for use in the study and treatment of solid tumors harboring Trk alterations supporting its application in preclinical and clinical oncology research focused on Trk-driven malignancies
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