Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Larotrectinib sulfate | 1223405-08-0 | 99.0% | 1 ML
Supplier: Medchemexpress LLC HY12866A10MM/1ML
Larotrectinib sulfate is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).
- ATP-competitive oral inhibitor
- Selective inhibitor of TRK family receptors (TRKA, B, and C)
- Low nanomolar 50% inhibitory concentrations against all three isoforms
- Greater than 1,000-fold selectivity relative to other kinases
- Demonstrates dose-dependent inhibition of cell proliferation
- Reduces tyrosine phosphorylation of TRKA and downstream signal transduction
- Well tolerated in GLP toxicology studies
- Reduces leukemic infiltration to undetectable levels in bone marrow and spleen
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?