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Medchemexpress LLC Lartesertib | 2495096-26-7 | C23H21FN6O3 | 100 MG
Supplier: Medchemexpress LLC HY150617100MG
Lartesertib is a highly potent inhibitor of the serine/threonine protein kinase ATM. It can inhibit the growth of multiple hematopoietic cell lines and, when combined with ATR inhibitors, promotes tumor cell death and activates the immune signaling pathway. This compound also demonstrates anti-tumor activity and alters the tumor microenvironment in the MC-38 mouse tumor model, leading to changes in PD-L1 expression and immune cell populations.
- Highly potent inhibitor of the serine/threonine protein kinase ATM.
- Inhibits the growth of various hematopoietic cell lines.
- Promotes tumor cell death in combination with ATR inhibitors.
- Activates the immune signaling pathway.
- Demonstrates anti-tumor activity.
- Alters the tumor microenvironment.
- Upregulates PD-L1 on immune and tumor cells.
- Modulates tumor immune cell populations.
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