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Cayman Chemical LCC-12formate 1mg
SDP

Supplier:  Cayman Chemical 389291 MG

Encompass_Preferred

A STING antagonist binds to the STING cyclic dinucleotide binding site (Kd 4.03 nM) and inhibits 23-cGAMP-induced Ifnb expression in MEFs BMDMs and HFFs (IC50s 127.5 107.1 and 502.8 nM respectively) impairs recruitment of IRF3 or TBK1 to the STING signalosome in HEK293T cells overexpressing tagged wild-type or SAVI-linked mutant STING and IRF3 or TBK1 as well as inhibits HSV-1-induced translocation of STING from the ER to the Golgi at 1 UM increases survival and reduces Ifnb mRNA levels in the Trex1-/- mouse model of Aicardi-Goutières syndrome at 5 mg/kg

Catalog No. 50-291-8803


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