Medchemexpress LLC LDN-214117 | 1627503-67-6 | 99.5% | 419.52 | 100 MG

Supplier:  Medchemexpress LLC HY16712100MG

LDN-214117 is an orally active, well-tolerated ALK2 inhibitor demonstrating high selectivity and low cytotoxicity for ALK2 (IC50 24 nM). It also functions as a specific bone morphogenetic proteins (BMPs) signaling inhibitor, selectively targeting BMP6 (IC50 100 nM). This compound is valuable in research for fibrodysplasia ossificans progressiva (FOP) and diffuse intrinsic pontine glioma (DIPG).

• Highly selective ALK2 inhibitor (IC50 24 nM), also inhibits ALK1, ALK3, and ALK5.
• Selectively inhibits BMP6, BMP2, and BMP4 signaling, and TGF-β1-induced transcriptional activity.
• Modulates gene regulation for ID1 targeting in cells.
• Reduces viability, proliferation, and induces apoptosis in LCLC-103H cells.
• Suppresses LCLC-103H wound healing, chemotaxis, and hinders spheroid growth.
• Well-tolerated in mice.

Catalog No. 50-003-90749