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Apexbio Technology LLC LED209 245342-14-7 5mg
Supplier: Apexbio Technology LLC B59025
LED209 (CAS 245342-14-7) is a small-molecule inhibitor targeting the bacterial histidine sensor kinase QseC It is designed to selectively inhibit QseC thereby disrupting the phosphorylation-mediated signaling essential for the regulation of virulence gene expression in bacteria LED209 exerts its biological activity primarily through inhibition of the interaction between signaling molecules and QseC In cell-based studies LED209 demonstrates inhibitory activity with an IC50 value of less than 10 M Notably it suppresses the expression and secretion of bacterial virulence factors such as EspA and EspB and inhibits formation of attaching and effacing lesions in cultured epithelial cells infected by pathogenic Escherichia coli (EHEC) Based on these pharmacological properties LED209 holds research potential in the study of bacterial pathogenesis and the development of therapeutic alternatives to traditional antibiotics
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