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Medchemexpress LLC Lenalidomide | 191732-72-6 | 99.9% | 5 G
Supplier: Medchemexpress LLC HYA00035G
Lenalidomide is an orally active immunomodulator derived from Thalidomide, functioning as a molecular glue. It primarily targets ubiquitin E3 ligase cereblon (CRBN) to induce selective degradation of key lymphoid transcription factors, demonstrating significant activity against various cancers.
- Acts as a ligand for ubiquitin E3 ligase cereblon (CRBN)
- Causes selective ubiquitination and degradation of IKZF1 and IKZF3
- Inhibits the growth of mature B-cell lymphomas and multiple myeloma
- Induces IL-2 release and stimulates T cell proliferation
- Suppresses pro-inflammatory cytokines (TNF-α, IL-1, IL-6, IL-12)
- Enhances anti-inflammatory cytokine IL-10 production
- Displays antiproliferative activity against human cell lines
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